Heterogeneous gene expression changes in colorectal cancer cells share the WNT pathway in response to growth suppression by APHS-mediated COX-2 inhibition

Cyclooxygenase-2 (COX-2), the prostaglandin (PG)-synthesizing enzyme overexpressed in colorectal cancer (CRC), has pleiotropic, cancer-promoting effects. COX-2 inhibitors (CIBs) interfere with many cancer-associated processes and show promising antineoplastic activity, however, a common mechanism of...

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Bibliografiske detaljer
Main Authors: Humar, Bostjan, McNoe, Les, Dunbier, Anita, Heathcott, Rosemary, Braithwaite, Antony W, Reeve, Anthony E
Format: Artigo
Sprog:Inglês
Udgivet: Dove Medical Press 2008
Fag:
Original Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2721360/
https://ncbi.nlm.nih.gov/pubmed/19707365
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