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Ca(2+) binding by domain 2 plays a critical role in the activation and stabilization of gelsolin
Gelsolin consists of six homologous domains (G1–G6), each containing a conserved Ca-binding site. Occupation of a subset of these sites enables gelsolin to sever and cap actin filaments in a Ca-dependent manner. Here, we present the structures of Ca-free human gelsolin and of Ca-bound human G1–G3 in...
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| 主要な著者: | , , , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
National Academy of Sciences
2009
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2720848/ https://ncbi.nlm.nih.gov/pubmed/19666512 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0812374106 |
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