Helix Straightening as an Activation Mechanism in the Gelsolin Superfamily of Actin Regulatory Proteins

Villin and gelsolin consist of six homologous domains of the gelsolin/cofilin fold (V1–V6 and G1–G6, respectively). Villin differs from gelsolin in possessing at its C terminus an unrelated seventh domain, the villin headpiece. Here, we present the crystal structure of villin domain V6 in an environ...

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Autores principales: Wang, Hui, Chumnarnsilpa, Sakesit, Loonchanta, Anantasak, Li, Qiang, Kuan, Yang-Mei, Robine, Sylvie, Larsson, Mårten, Mihalek, Ivana, Burtnick, Leslie D., Robinson, Robert C.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2009
Materias:
Protein Structure and Folding
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2755850/
https://ncbi.nlm.nih.gov/pubmed/19491107
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.019760
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