Quantitation of Aurora Kinase A Gene Copy Number in Urine Sediments and Bladder Cancer Detection

BACKGROUND: Chromosome missegregation and the resulting aneuploidy is a common change in neoplasia. The Aurora kinase A (AURKA) gene, which encodes a key regulator of mitosis, is frequently amplified and/or overexpressed in cancer cells, and the level of AURKA amplification is associated with the le...

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Hauptverfasser: Park, Hong-Seok, Park, Weon Seo, Bondaruk, Jolanta, Tanaka, Noriyoshi, Katayama, Hiroshi, Lee, Sangkyou, Spiess, Philippe E., Steinberg, Jordan R., Wang, Zhi, Katz, Ruth L., Dinney, Colin, Elias, Keren J., Lotan, Yair, Naeem, Rizwan C., Baggerly, Keith, Sen, Subrata, Grossman, H. Barton, Czerniak, Bogdan
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2008
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Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2720731/
https://ncbi.nlm.nih.gov/pubmed/18812553
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jnci/djn304
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