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Mice with a targeted mutation in the thyroid hormone β receptor gene exhibit impaired growth and resistance to thyroid hormone

Patients with mutations in the thyroid hormone receptor β (TRβ) gene manifest resistance to thyroid hormone (RTH), resulting in a constellation of variable phenotypic abnormalities. To understand the molecular basis underlying the action of mutant TRβ in vivo, we generated mice with a targeted mutat...

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Uloženo v:
Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Kaneshige, Masahiro, Kaneshige, Kumiko, Zhu, Xu-guang, Dace, Alexandra, Garrett, Lisa, Carter, Todd A., Kazlauskaite, Rasa, Pankratz, Daniel G., Wynshaw-Boris, Anthony, Refetoff, Samuel, Weintraub, Bruce, Willingham, Mark C., Barlow, Carrolee, Cheng, Sheue-yann
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2000
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC27204/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11069286/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.230285997
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