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Dopamine Signaling in the Dorsal Striatum Is Essential for Motivated Behaviors: Lessons from Dopamine-deficient Mice
Genetically engineered mice that lack tyrosine hydroxylase in all dopaminergic neurons become hypoactive and aphagic and they starve by 4 weeks of age. However, they can be rescued by daily treatment with L-dopa, which restores activity and feeding for about 10 hours. Thus, these mice can be examine...
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| Hovedforfatter: | |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2008
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| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2720267/ https://ncbi.nlm.nih.gov/pubmed/18591467 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1196/annals.1417.003 |
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