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Dopamine-Deficient Mice Are Hypersensitive to Dopamine Receptor Agonists
Dopamine-deficient (DA−/−) mice were created by targeted inactivation of the tyrosine hydroxylase gene in dopaminergic neurons. The locomotor activity response of these mutants to dopamine D1 or D2 receptor agonists and l-3,4-dihydroxyphenylalanine (l-DOPA) was 3- to 13-fold greater than the respons...
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| Publicado no: | J Neurosci |
|---|---|
| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Society for Neuroscience
2000
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6772455/ https://ncbi.nlm.nih.gov/pubmed/10844009 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.20-12-04405.2000 |
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