Influence of sulfur oxidation state and steric bulk upon trifluoromethyl ketone (TFK) binding kinetics to carboxylesterases and fatty acid amide hydrolase (FAAH)

Carboxylesterases metabolize numerous exogenous and endogenous ester-containing compounds including the chemotherapeutic agent CPT-11, anti-influenza viral agent oseltamivir and many agrochemicals. Trifluoromethyl ketone (TFK)-containing compounds with a sulfur atom beta to the ketone moiety are som...

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Bibliografiske detaljer
Main Authors: Wheelock, Craig E., Nishi, Kosuke, Ying, Andy, Jones, Paul D., Colvin, Michael E., Olmstead, Marilyn M., Hammock, Bruce D.
Format: Artigo
Sprog:Inglês
Udgivet: 2007
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2720161/
https://ncbi.nlm.nih.gov/pubmed/18023188
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2007.10.081
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