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EARLY AND LATE CONTRIBUTIONS OF GLUTAMATE AND CGRP TO MECHANICAL SENSITIZATION BY ENDOTHELIN-1
Intraplantar injection of endothelin-1 (ET-1) (1.5-10 μM) in the rat produces mechanical allodynia. Here we identify the receptor subtypes for ET-1, glutamate and CGRP critical to such allodynia. Antagonism of ET(A) or ET(B) receptors alone, by BQ123 or BQ788, respectively, only partially suppressed...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2720062/ https://ncbi.nlm.nih.gov/pubmed/19559390 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jpain.2009.01.265 |
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