Polyethylenimine-based siRNA nanocomplexes reprogram tumor-associated dendritic cells via TLR5 to elicit therapeutic antitumor immunity

The success of clinically relevant immunotherapies requires reversing tumor-induced immunosuppression. Here we demonstrated that linear polyethylenimine-based (PEI-based) nanoparticles encapsulating siRNA were preferentially and avidly engulfed by regulatory DCs expressing CD11c and programmed cell...

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Main Authors: Cubillos-Ruiz, Juan R., Engle, Xavier, Scarlett, Uciane K., Martinez, Diana, Barber, Amorette, Elgueta, Raul, Wang, Li, Nesbeth, Yolanda, Durant, Yvon, Gewirtz, Andrew T., Sentman, Charles L., Kedl, Ross, Conejo-Garcia, Jose R.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2009
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2719935/
https://ncbi.nlm.nih.gov/pubmed/19620771
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI37716
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