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Fulvene-5 potently inhibits NADPH oxidase 4 and blocks the growth of endothelial tumors in mice

Hemangiomas are the most common type of tumor in infants. As they are endothelial cell–derived neoplasias, their growth can be regulated by the autocrine-acting Tie2 ligand angiopoietin 2 (Ang2). Using an experimental model of human hemangiomas, in which polyoma middle T–transformed brain endothelia...

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Detalhes bibliográficos
Main Authors: Bhandarkar, Sulochana S., Jaconi, Marisa, Fried, Levi E., Bonner, Michael Y., Lefkove, Benjamin, Govindarajan, Baskaran, Perry, Betsy N., Parhar, Ravi, Mackelfresh, Jamie, Sohn, Allie, Stouffs, Michael, Knaus, Ulla, Yancopoulos, George, Reiss, Yvonne, Benest, Andrew V., Augustin, Hellmut G., Arbiser, Jack L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2719922/
https://ncbi.nlm.nih.gov/pubmed/19620773
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI33877
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