Synthesis and Biological Evaluation of Novel Carbon-11 Labeled Pyridyl Ethers: Candidate Ligands for In Vivo Imaging of α4β2 Nicotinic Acetylcholine Receptors (α4β2-nAChRs) in the brain with Positron Emission Tomography

The most abundant subtype of cerebral nicotinic acetylcholine receptors (nAChR), α4β2, plays a critical role in various brain functions and pathological states. Imaging agents suitable for visualization and quantification of α4β2 nAChRs by positron emission tomography (PET) would present unique oppo...

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Autors principals: Gao, Yongjun, Ravert, Hayden T., Kuwabara, Hiroto, Xiao, Yingxian, Endres, Christopher J., Hilton, John, Holt, Daniel P., Kumar, Anil, Alexander, Mohab, Wong, Dean F., Dannals, Robert F., Horti, Andrew G.
Format: Artigo
Idioma:Inglês
Publicat: 2009
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2719852/
https://ncbi.nlm.nih.gov/pubmed/19481945
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2009.05.021
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