Multipolar Spindle Pole Coalescence Is a Major Source of Kinetochore Mis-Attachment and Chromosome Mis-Segregation in Cancer Cells

Many cancer cells display a CIN (Chromosome Instability) phenotype, by which they exhibit high rates of chromosome loss or gain at each cell cycle. Over the years, a number of different mechanisms, including mitotic spindle multipolarity, cytokinesis failure, and merotelic kinetochore orientation, h...

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Detaylı Bibliyografya
Asıl Yazarlar: Silkworth, William T., Nardi, Isaac K., Scholl, Lindsey M., Cimini, Daniela
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Public Library of Science 2009
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2719800/
https://ncbi.nlm.nih.gov/pubmed/19668340
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0006564
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