At Low Concentrations, 3,4-Dihydroxyphenylacetic acid (DOPAC) Binds Non-covalently to α-Synuclein and Prevents Its Fibrillation

Several studies have shown that catecholamines can inhibit the fibrillation of α-synuclein, a small presynaptic protein whose aggregation is believed to be a critical step in the etiology of Parkinson's disease and several other neurodegenerative disorders. However, the mechanism of this inhibi...

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Главные авторы: Zhou, Wenbo, Gallagher, Amy, Hong, Dong-Pyo, Long, Chunmei, Fink, Anthony L., Uversky, Vladimir N.
Формат: Artigo
Язык:Inglês
Опубликовано: 2009
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2719782/
https://ncbi.nlm.nih.gov/pubmed/19328209
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2009.03.053
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