SYNTHESIS AND EVALUATION OF LIGANDS FOR D(2)-LIKE RECEPTORS: THE ROLE OF COMMON PHARMACOPHORIC GROUPS

Arylcycloalkylamines, such as phenyl piperidines and piperazines and their arylalkyl substituents, constitute pharmacophoric groups exemplified in several antipsychotic agents. A review of previous reports indicates that arylalkyl substituents can improve the potency and selectivity of the binding a...

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Detalhes bibliográficos
Main Authors: Sikazwe, Donald M. N., Nkansah, Nancy T., Altundas, Ramazan, Zhu, Xue Y., Roth, Bryan L., Setola, Vincent, Ablordeppey, Seth Y.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2719767/
https://ncbi.nlm.nih.gov/pubmed/19155177
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2008.12.054
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