Oxidative Stress Renders Retinal Pigment Epithelial Cells Susceptible to Complement-mediated Injury

Uncontrolled activation of the alternative pathway of complement is thought to be associated with age-related macular degeneration (AMD). The alternative pathway is continuously activated in the fluid phase, and tissue surfaces require continuous complement inhibition to prevent spontaneous autologo...

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Auteurs principaux: Thurman, Joshua M., Renner, Brandon, Kunchithapautham, Kannan, Ferreira, Viviana P., Pangburn, Michael K., Ablonczy, Zsolt, Tomlinson, Stephen, Holers, V. Michael, Rohrer, Bärbel
Format: Artigo
Langue:Inglês
Publié: American Society for Biochemistry and Molecular Biology 2009
Sujets:
Molecular Basis of Cell and Developmental Biology
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2719331/
https://ncbi.nlm.nih.gov/pubmed/19386604
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M808166200
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