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Experimental treatment of pancreatic cancer with two novel histone deacetylase inhibitors

AIM: To investigate in vitro and in vivo treatment with histone deacetylase inhibitors NVP-LAQ824 and NVP-LBH589 in pancreatic cancer. METHODS: Cell-growth inhibition by NVP-LAQ824 and NVP-LBH589 was studied in vitro in 8 human pancreatic cancer cell lines using the 3-(4,5-dimethylthiazole-2-yl)-2,5...

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Autors principals: Haefner, Martin, Bluethner, Thilo, Niederhagen, Manuel, Moebius, Christian, Wittekind, Christian, Mossner, Joachim, Caca, Karel, Wiedmann, Marcus
Format: Artigo
Idioma:Inglês
Publicat: The WJG Press and Baishideng 2008
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2719231/
https://ncbi.nlm.nih.gov/pubmed/18595135
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3748/wjg.14.3681
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