EGFRvIII expression and PTEN loss synergistically induce chromosomal instability and glial tumors

Glioblastomas often show activation of epidermal growth factor receptor (EGFR) and loss of PTEN (phosphatase and tensin homolog deleted on chromosome 10) tumor suppressor, but it is not known if these two genetic lesions act together to transform cells. To answer this question, we infected PTEN−/− n...

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Bibliografiske detaljer
Main Authors: Li, Li, Dutra, Amalia, Pak, Evgenia, Labrie, Joseph E., Gerstein, Rachel M., Pandolfi, Pier Paolo, Recht, Larry D., Ross, Alonzo H.
Format: Artigo
Sprog:Inglês
Udgivet: Duke University Press 2009
Fag:
Basic and Translational Investigations
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2718963/
https://ncbi.nlm.nih.gov/pubmed/18812521
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1215/15228517-2008-081
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