Association of genetic variants of methionine metabolism with methotrexate-induced CNS white matter changes in patients with primary CNS lymphoma

Methotrexate (MTX) is an important anticancer drug and the most efficient chemotherapy component in primary CNS lymphoma (PCNSL). A typical side effect of intravenous high-dose MTX is the occurrence of confluent CNS white matter changes (WMC). Because MTX directly interferes with methionine metaboli...

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Detalhes bibliográficos
Main Authors: Linnebank, Michael, Moskau, Susanna, Jürgens, Annika, Simon, Matthias, Semmler, Alexander, Orlopp, Katjana, Glasmacher, Axel, Bangard, Christopher, Vogt-Schaden, Marlies, Urbach, Horst, Schmidt-Wolf, Ingo G.H., Pels, Hendrik, Schlegel, Uwe
Formato: Artigo
Idioma:Inglês
Publicado em: Duke University Press 2009
Assuntos:
Basic and Translational Investigations
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2718955/
https://ncbi.nlm.nih.gov/pubmed/18806228
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1215/15228517-2008-082
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