Calcium-dependent enzyme activation and vacuole formation in the apical granular region of pancreatic acinar cells

The pancreatic acinar cell produces powerful digestive enzymes packaged in zymogen granules in the apical pole. Ca(2+) signals elicited by acetylcholine or cholecystokinin (CCK) initiate enzyme secretion by exocytosis through the apical membrane. Intracellular enzyme activation is normally kept to a...

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書誌詳細

出版年:	Proc Natl Acad Sci U S A
主要な著者:	Raraty, Michael, Ward, Jeremy, Erdemli, Gul, Vaillant, Camille, Neoptolemos, John P., Sutton, Robert, Petersen, Ole H.
フォーマット:	Artigo
言語:	Inglês
出版事項:	National Academy of Sciences 2000
主題:	Biological Sciences
オンライン･アクセス:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC27189/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11087863/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.97.24.13126
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