Calcium-dependent enzyme activation and vacuole formation in the apical granular region of pancreatic acinar cells

The pancreatic acinar cell produces powerful digestive enzymes packaged in zymogen granules in the apical pole. Ca(2+) signals elicited by acetylcholine or cholecystokinin (CCK) initiate enzyme secretion by exocytosis through the apical membrane. Intracellular enzyme activation is normally kept to a...

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Bibliografische Detailangaben

Veröffentlicht in:	Proc Natl Acad Sci U S A
Hauptverfasser:	Raraty, Michael, Ward, Jeremy, Erdemli, Gul, Vaillant, Camille, Neoptolemos, John P., Sutton, Robert, Petersen, Ole H.
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	National Academy of Sciences 2000
Schlagworte:	Biological Sciences
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC27189/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11087863/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.97.24.13126
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