Calcium-dependent enzyme activation and vacuole formation in the apical granular region of pancreatic acinar cells

The pancreatic acinar cell produces powerful digestive enzymes packaged in zymogen granules in the apical pole. Ca(2+) signals elicited by acetylcholine or cholecystokinin (CCK) initiate enzyme secretion by exocytosis through the apical membrane. Intracellular enzyme activation is normally kept to a...

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Detalles Bibliográficos

Publicado en:	Proc Natl Acad Sci U S A
Principais autores:	Raraty, Michael, Ward, Jeremy, Erdemli, Gul, Vaillant, Camille, Neoptolemos, John P., Sutton, Robert, Petersen, Ole H.
Formato:	Artigo
Idioma:	Inglês
Publicado:	National Academy of Sciences 2000
Assuntos:	Biological Sciences
Acceso en liña:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC27189/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11087863/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.97.24.13126
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