Repression of Runx2 by Androgen Receptor (AR) in Osteoblasts and Prostate Cancer Cells: AR Binds Runx2 and Abrogates Its Recruitment to DNA

Runx2 and androgen receptor (AR) are master transcription factors with pivotal roles in bone metabolism and prostate cancer (PCa). We dissected AR-mediated repression of Runx2 in dihydrotestosterone (DHT)-treated osteoblastic and PCa cells using reporter assays and endogenous Runx2 target genes. Rep...

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Autores principales: Baniwal, Sanjeev K., Khalid, Omar, Sir, Donna, Buchanan, Grant, Coetzee, Gerhard A., Frenkel, Baruch
Formato: Artigo
Lenguaje:Inglês
Publicado: The Endocrine Society 2009
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2718746/
https://ncbi.nlm.nih.gov/pubmed/19389811
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/me.2008-0470
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