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Direct Detection of Abortive RNA Transcripts in Vivo

During transcription initiation in vitro, RNA polymerase can engage in abortive initiation–the synthesis and release of short, 2 to 15 nucleotide, RNA transcripts–prior to productive initiation. It has not been known whether abortive initiation occurs in vivo. Using hybridization with locked nucleic...

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Detalhes bibliográficos
Main Authors: Goldman, Seth R., Ebright, Richard H., Nickels, Bryce E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2718712/
https://ncbi.nlm.nih.gov/pubmed/19443781
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1169237
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