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Failure of α-Galactosylceramide to Prevent Diabetes in Virus-Inducible Models of Type 1 Diabetes in the Rat

BACKGROUND: α-Galactosylceramide (α-GalCer) is an invariant natural killer T (iNKT) cell ligand that prevents type 1 diabetes in NOD mice. However, α-GalCer can activate or suppress immune responses, raising concern about its potential use in human diabetes. MATERIALS AND METHODS: To evaluate this t...

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Detalhes bibliográficos
Main Authors: Chopra, Prerna, diIorio, Philip, Pino, Steven C., Wilson, S. Brian, Phillips, Nancy E., Mordes, John P., Rossini, Aldo A., Greiner, Dale L., Shultz, Leonard D., Bortell, Rita
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2718559/
https://ncbi.nlm.nih.gov/pubmed/19414403
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