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Cell type-dependent proapoptotic role of Bcl2L12 revealed by a mutation concomitant with the disruption of the juxtaposed Irf3 gene
The generation of mice lacking the expression of the IRF3 transcription factor (Irf3(−/−) mice) has revealed its crucial role in the activation of the type I IFN response. The Bcl2l12 gene, encoding Bcl2L12 protein structurally related to the Bcl-2 family, was found to almost overlap with the Irf3 g...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2718395/ https://ncbi.nlm.nih.gov/pubmed/19617565 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0905702106 |
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