Genetic and chemical inhibition of IRF5 suppresses pre-existing mouse lupus-like disease

The transcription factor IRF5 has been implicated as a therapeutic target for the autoimmune disease systemic lupus erythematosus (SLE). However, IRF5 activation status during the disease course and the effects of IRF5 inhibition after disease onset are unclear. Here, we show that SLE patients in bo...

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Bibliografiset tiedot
Julkaisussa:Nat Commun
Päätekijät: Ban, Tatsuma, Kikuchi, Masako, Sato, Go R., Manabe, Akio, Tagata, Noriko, Harita, Kayo, Nishiyama, Akira, Nishimura, Kenichi, Yoshimi, Ryusuke, Kirino, Yohei, Yanai, Hideyuki, Matsumoto, Yoshiko, Suzuki, Shuichi, Hihara, Hiroe, Ito, Masashi, Tsukahara, Kappei, Yoshimatsu, Kentaro, Yamamoto, Tadashi, Taniguchi, Tadatsugu, Nakajima, Hideaki, Ito, Shuichi, Tamura, Tomohiko
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Nature Publishing Group UK 2021
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC8290003/
https://ncbi.nlm.nih.gov/pubmed/34282144
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-24609-4
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