Biosynthesis of the salinosporamide A polyketide synthase substrate chloroethylmalonyl-coenzyme A from S-adenosyl-l-methionine

Polyketides are among the major classes of bioactive natural products used to treat microbial infections, cancer, and other diseases. Here we describe a pathway to chloroethylmalonyl-CoA as a polyketide synthase building block in the biosynthesis of salinosporamide A, a marine microbial metabolite w...

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Detaylı Bibliyografya
Asıl Yazarlar: Eustáquio, Alessandra S., McGlinchey, Ryan P., Liu, Yuan, Hazzard, Christopher, Beer, Laura L., Florova, Galina, Alhamadsheh, Mamoun M., Lechner, Anna, Kale, Andrew J., Kobayashi, Yoshihisa, Reynolds, Kevin A., Moore, Bradley S.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 2009
Konular:
Biological Sciences
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2718359/
https://ncbi.nlm.nih.gov/pubmed/19590008
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0901237106
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