Biosynthesis of the salinosporamide A polyketide synthase substrate chloroethylmalonyl-coenzyme A from S-adenosyl-l-methionine

Polyketides are among the major classes of bioactive natural products used to treat microbial infections, cancer, and other diseases. Here we describe a pathway to chloroethylmalonyl-CoA as a polyketide synthase building block in the biosynthesis of salinosporamide A, a marine microbial metabolite w...

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Detalhes bibliográficos
Main Authors: Eustáquio, Alessandra S., McGlinchey, Ryan P., Liu, Yuan, Hazzard, Christopher, Beer, Laura L., Florova, Galina, Alhamadsheh, Mamoun M., Lechner, Anna, Kale, Andrew J., Kobayashi, Yoshihisa, Reynolds, Kevin A., Moore, Bradley S.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2009
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2718359/
https://ncbi.nlm.nih.gov/pubmed/19590008
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0901237106
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