Biosynthesis of the salinosporamide A polyketide synthase substrate chloroethylmalonyl-coenzyme A from S-adenosyl-l-methionine

Polyketides are among the major classes of bioactive natural products used to treat microbial infections, cancer, and other diseases. Here we describe a pathway to chloroethylmalonyl-CoA as a polyketide synthase building block in the biosynthesis of salinosporamide A, a marine microbial metabolite w...

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Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Eustáquio, Alessandra S., McGlinchey, Ryan P., Liu, Yuan, Hazzard, Christopher, Beer, Laura L., Florova, Galina, Alhamadsheh, Mamoun M., Lechner, Anna, Kale, Andrew J., Kobayashi, Yoshihisa, Reynolds, Kevin A., Moore, Bradley S.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: National Academy of Sciences 2009
Gaiak:
Biological Sciences
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC2718359/
https://ncbi.nlm.nih.gov/pubmed/19590008
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0901237106
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