A Model of Action Potentials and Fast Ca(2+) Dynamics in Pancreatic β-Cells

We examined the ionic mechanisms mediating depolarization-induced spike activity in pancreatic β-cells. We formulated a Hodgkin-Huxley-type ionic model for the action potential (AP) in these cells based on voltage- and current-clamp results together with measurements of Ca(2+) dynamics in wild-type...

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Detalhes bibliográficos
Main Authors: Fridlyand, L.E., Jacobson, D.A., Kuznetsov, A., Philipson, L.H.
Formato: Artigo
Idioma:Inglês
Publicado em: The Biophysical Society 2009
Assuntos:
Biophysical Theory and Modeling
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2718303/
https://ncbi.nlm.nih.gov/pubmed/19383458
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2009.01.029
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