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Ion channels and regulation of insulin secretion in human β-cells: A computational systems analysis
In mammals an increase in glucose leads to block of ATP dependent potassium channels in pancreatic β cells leading to membrane depolarization. This leads to the repetitive firing of action potentials that increases calcium influx and triggers insulin granule exocytosis. Several important differences...
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| Asıl Yazarlar: | , , |
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| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
Landes Bioscience
2013
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3662377/ https://ncbi.nlm.nih.gov/pubmed/23624892 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/isl.24166 |
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