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Glucose sensing in the pancreatic beta cell: a computational systems analysis

BACKGROUND: Pancreatic beta-cells respond to rising blood glucose by increasing oxidative metabolism, leading to an increased ATP/ADP ratio in the cytoplasm. This leads to a closure of K(ATP )channels, depolarization of the plasma membrane, influx of calcium and the eventual secretion of insulin. Su...

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Bibliografiske detaljer
Main Authors: Fridlyand, Leonid E, Philipson, Louis H
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2010
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2896931/
https://ncbi.nlm.nih.gov/pubmed/20497556
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-4682-7-15
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