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Asymmetric [4 + 3] Cyloadditions between Vinylcarbenoids and Dienes: Application to the Total Synthesis of the Natural Product (−)-5-epi-Vibsanin E

The total synthesis of (−)-5-epi-vibsanin E (2) has been achieved in 18 steps. The synthesis combines the rhodium-catalyzed [4 + 3] cycloaddition between a vinylcarbenoid and a diene to rapidly generate the tricyclic core with an effective end game strategy to introduce the remaining side-chains. Th...

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Autori principali: Schwartz, Brett D., Denton, Justin R., Lian, Yajing, Davies, Huw M. L., Williams, Craig M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2009
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2717789/
https://ncbi.nlm.nih.gov/pubmed/19445507
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja9019484
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