Crystal structure of isoflurane bound to integrin LFA-1 supports a unified mechanism of volatile anesthetic action in the immune and central nervous systems

Volatile anesthetics (VAs), such as isoflurane, induce a general anesthetic state by binding to specific targets (i.e., ion channels) in the central nervous system (CNS). Simultaneously, VAs modulate immune functions, possibly via direct interaction with alternative targets on leukocytes. One such t...

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Hlavní autoři: Zhang, Hongmin, Astrof, Nathan S., Liu, Jin-Huan, Wang, Jia-huai, Shimaoka, Motomu
Médium: Artigo
Jazyk:Inglês
Vydáno: The Federation of American Societies for Experimental Biology 2009
Témata:
Research Communications
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2717780/
https://ncbi.nlm.nih.gov/pubmed/19332643
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.09-129908
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