Blood-Brain Barrier Disruption and Intra-Arterial Methotrexate-Based Therapy for Newly Diagnosed Primary CNS Lymphoma: A Multi-Institutional Experience

PURPOSE: Primary CNS lymphoma (PCNSL) is confined to the CNS and/or the eyes at presentation and is usually initially treated with intravenous methotrexate-based chemotherapy and whole-brain radiotherapy (WBRT). However, the intact blood-brain barrier (BBB) can limit diffusion of methotrexate into b...

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Bibliografski detalji
Glavni autori: Angelov, Lilyana, Doolittle, Nancy D., Kraemer, Dale F., Siegal, Tali, Barnett, Gene H., Peereboom, David M., Stevens, Glen, McGregor, John, Jahnke, Kristoph, Lacy, Cynthia A., Hedrick, Nancy A., Shalom, Edna, Ference, Sandra, Bell, Susan, Sorenson, Lisa, Tyson, Rose Marie, Haluska, Marianne, Neuwelt, Edward A.
Format: Artigo
Jezik:Inglês
Izdano: American Society of Clinical Oncology 2009
Teme:
Original Reports
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2717756/
https://ncbi.nlm.nih.gov/pubmed/19451444
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/JCO.2008.19.3789
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