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Blood-Brain Barrier Disruption and Intra-Arterial Methotrexate-Based Therapy for Newly Diagnosed Primary CNS Lymphoma: A Multi-Institutional Experience

PURPOSE: Primary CNS lymphoma (PCNSL) is confined to the CNS and/or the eyes at presentation and is usually initially treated with intravenous methotrexate-based chemotherapy and whole-brain radiotherapy (WBRT). However, the intact blood-brain barrier (BBB) can limit diffusion of methotrexate into b...

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Main Authors: Angelov, Lilyana, Doolittle, Nancy D., Kraemer, Dale F., Siegal, Tali, Barnett, Gene H., Peereboom, David M., Stevens, Glen, McGregor, John, Jahnke, Kristoph, Lacy, Cynthia A., Hedrick, Nancy A., Shalom, Edna, Ference, Sandra, Bell, Susan, Sorenson, Lisa, Tyson, Rose Marie, Haluska, Marianne, Neuwelt, Edward A.
格式: Artigo
語言:Inglês
出版: American Society of Clinical Oncology 2009
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2717756/
https://ncbi.nlm.nih.gov/pubmed/19451444
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/JCO.2008.19.3789
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