Multiple quantum solid-state NMR indicates a parallel, not antiparallel, organization of β-sheets in Alzheimer's β-amyloid fibrils

Senile plaques associated with Alzheimer's disease contain deposits of fibrils formed by 39- to 43-residue β-amyloid peptides with possible neurotoxic effects. X-ray diffraction measurements on oriented fibril bundles have indicated an extended β-sheet structure for Alzheimer's β-amyloid fibrils and...

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Dades bibliogràfiques

Publicat a:	Proc Natl Acad Sci U S A
Autors principals:	Antzutkin, Oleg N., Balbach, John J., Leapman, Richard D., Rizzo, Nancy W., Reed, Jennifer, Tycko, Robert
Format:	Artigo
Idioma:	Inglês
Publicat:	National Academy of Sciences 2000
Matèries:	Biological Sciences
Accés en línia:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC27175/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11069287/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.230315097
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