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Multiple quantum solid-state NMR indicates a parallel, not antiparallel, organization of β-sheets in Alzheimer's β-amyloid fibrils

Senile plaques associated with Alzheimer's disease contain deposits of fibrils formed by 39- to 43-residue β-amyloid peptides with possible neurotoxic effects. X-ray diffraction measurements on oriented fibril bundles have indicated an extended β-sheet structure for Alzheimer's β-amyloid f...

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Bibliografiske detaljer
Main Authors: Antzutkin, Oleg N., Balbach, John J., Leapman, Richard D., Rizzo, Nancy W., Reed, Jennifer, Tycko, Robert
Format: Artigo
Sprog:Inglês
Udgivet: The National Academy of Sciences 2000
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC27175/
https://ncbi.nlm.nih.gov/pubmed/11069287
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