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Molecular mechanisms of amyloid-β peptide fibril and oligomer formation: NMR-based challenges

To completely treat and ultimately prevent dementia, it is essential to elucidate its pathogenic mechanisms in detail. There are two major hypotheses for the pathogenesis of Alzheimer’s dementia: the β-amyloid (Aβ) hypothesis and the tau hypothesis. The modified amyloid hypothesis, which proposes th...

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Autore principale: Hidekazu Hiroaki
Natura: Artigo
Lingua:Inglês
Pubblicazione: The Biophysical Society of Japan 2023-03-01
Serie:Biophysics and Physicobiology
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Accesso online:https://doi.org/10.2142/biophysico.bppb-v20.0007
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