Selectivity and Cooperativity of Modulatory Ions in a Neurotransmitter Receptor

Ions play a modulatory role in many proteins. Kainate receptors, members of the ionotropic glutamate receptor family, require both monovalent anions and cations in the extracellular milieu for normal channel activity. Molecular dynamics simulations and extensive relative binding free energy calculat...

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Bibliografiske detaljer
Main Authors: Vijayan, Ranjit, Plested, Andrew J.R., Mayer, Mark L., Biggin, Philip C.
Format: Artigo
Sprog:Inglês
Udgivet: The Biophysical Society 2009
Fag:
Biophysical Theory and Modeling
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2717295/
https://ncbi.nlm.nih.gov/pubmed/19254535
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2008.11.039
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