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Ions and Inhibitors in the Binding Site of HIV Protease: Comparison of Monte Carlo Simulations and the Linearized Poisson-Boltzmann Theory

Proteins can be influenced strongly by the electrolyte in which they are dissolved, and we wish to model, understand, and ultimately control such ionic effects. Relatively detailed Monte Carlo (MC) ion simulations are needed to capture biologically important properties of ion channels, but a simpler...

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Détails bibliographiques
Auteurs principaux: Boda, Dezső, Valiskó, Mónika, Henderson, Douglas, Gillespie, Dirk, Eisenberg, Bob, Gilson, Michael K.
Format: Artigo
Langue:Inglês
Publié: The Biophysical Society 2009
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2717253/
https://ncbi.nlm.nih.gov/pubmed/19217848
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2008.10.059
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