Statins Inhibit Rho Kinase Activity in Patients with Atherosclerosis

BACKGROUND: In addition to inhibiting cholesterol synthesis, statins (HMG-CoA reductase inhibitors) decrease the formation of isoprenoid intermediates required for the activation of key signaling pathways, including Rho/Rho kinase (ROCK). In experimental settings, statins inhibit ROCK and reverse va...

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Detalhes bibliográficos
Main Authors: Nohria, Anju, Prsic, Adnan, Liu, Ping-Yen, Okamoto, Ryuji, Creager, Mark A., Selwyn, Andrew, Liao, James K., Ganz, Peter
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2717178/
https://ncbi.nlm.nih.gov/pubmed/19167712
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.atherosclerosis.2008.12.023
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