IL-4Rα Responsiveness of Non-CD4 T Cells Contributes to Resistance in Schistosoma mansoni Infection in Pan-T Cell-Specific IL-4Rα-Deficient Mice

Interleukin (IL)-4 and IL-13 are T helper 2 cytokines whose biological functions are induced through a common IL-4 receptor α chain (IL-4Rα). CD4(+) T cell-specific IL-4Rα-mediated signaling drives susceptibility to Leishmania major infection, but is not essential to host survival following Schistos...

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Main Authors: Dewals, Benjamin, Hoving, Jennifer C., Leeto, Mosiuoa, Marillier, Reece G., Govender, Umeshree, Cutler, Antony J., Horsnell, William G.C., Brombacher, Frank
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2009
Assuntos:
Regular Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2716945/
https://ncbi.nlm.nih.gov/pubmed/19628763
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2009.090137
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