A potent peptidomimetic inhibitor of botulinum neurotoxin serotype A has a very different conformation than SNAP-25 substrate

Botulinum neurotoxin serotype A is the most lethal of all known toxins. Here, we report the crystal structure, along with SAR data, of the zinc metalloprotease domain of BoNT/A bound to a potent peptidomimetic inhibitor (Ki = 41 nM) that resembles the local sequence of the SNAP-25 substrate. Surpris...

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Autores principales: Zuniga, Jorge E., Schmidt, James J., Fenn, Timothy, Burnett, James C., Araç, Demet, Gussio, Rick, Stafford, Robert G., Badie, Shirin S., Bavari, Sina, Brunger, Axel T.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2008
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2716802/
https://ncbi.nlm.nih.gov/pubmed/18940613
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2008.07.011
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