Functional and Structural Characterization of Factor Xa Dimer in Solution

Previous studies showed that binding of water-soluble phosphatidylserine (C6PS) to bovine factor Xa (FXa) leads to Ca(2+)-dependent dimerization in solution. We report the effects of Ca(2+), C6PS, and dimerization on the activity and structure of human and bovine FXa. Both human and bovine dimers ar...

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Bibliographic Details
Main Authors: Chattopadhyay, Rima, Iacob, Roxana, Sen, Shalmali, Majumder, Rinku, Tomer, Kenneth B., Lentz, Barry R.
Format: Artigo
Language:Inglês
Published: The Biophysical Society 2009
Subjects:
Membrane
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2716635/
https://ncbi.nlm.nih.gov/pubmed/19186135
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2008.10.013
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