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Loop Dynamics of the Extracellular Domain of Human Tissue Factor and Activation of Factor VIIa

In the crystal structure of the complex between the soluble extracellular domain of tissue factor (sTF) and active-site-inhibited VIIa, residues 91 and 92 in the Pro(79)-Pro(92) loop of sTF interact with the catalytic domain of VIIa. It is not known, however, whether this loop has a role in alloster...

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Hlavní autoři: Minazzo, Agnese S., Darlington, Reuben C., Ross, J.B. Alexander
Médium: Artigo
Jazyk:Inglês
Vydáno: The Biophysical Society 2009
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2716462/
https://ncbi.nlm.nih.gov/pubmed/19167313
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2008.10.018
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