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Kinetic Study of β-Amyloid residue accessibility using Reductive Alkylation and Mass Spectrometry

Beta-amyloid peptide (Aβ) is the major protein constituent found in senile plaques in Alzheimer's disease (AD). It is believed that Aβ plays a role in neurodegeneration associated with AD and that its toxicity is related to its structure or aggregation state. In this study, an approach based on...

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Detalhes bibliográficos
Main Authors: Ramos, Irina, Fabris, Dan, Qi, Wei, Fernandez, Erik J., Good, Theresa A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2716430/
https://ncbi.nlm.nih.gov/pubmed/19418563
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/bit.22367
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