Erythropoietin overrides the triggering effect of DNA platination products in a mouse model of Cisplatin-induced neuropathy

BACKGROUND: Cisplatin mediates its antineoplastic activity by formation of distinct DNA intrastrand cross links. The clinical efficacy and desirable dose escalations of cisplatin are restricted by the accumulation of DNA lesions in dorsal root ganglion (DRG) cells leading to sensory polyneuropathy (...

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Autores principales: Yoon, Min-Suk, Katsarava, Zaza, Obermann, Mark, Schäfers, Maria, Liedert, Bernd, Dzagnidze, Anna, Kribben, Andreas, Egensperger, Rupert, Limmroth, Volker, Diener, Hans-Christoph, Thomale, Juergen
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2009
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2716353/
https://ncbi.nlm.nih.gov/pubmed/19602296
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2202-10-77
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