The PD-1/PD-L pathway is up-regulated during IL-12-induced suppression of EAE mediated by IFN-gamma

Experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis (MS), is mediated by autoantigen-specific T-helper1 (Th1) cells. IL-12, an inducer of Th1 cell development, exerts immunomodulatory effects in EAE. Programmed death-1 (PD-1) and PD-1 ligand (PD-L), new members of...

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Bibliographische Detailangaben
Hauptverfasser: Cheng, Xiaodong, Zhao, Zhao, Ventura, Elvira, Gran, Bruno, Shindler, Kenneth S., Rostami, Abdolmohamad
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2007
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2716290/
https://ncbi.nlm.nih.gov/pubmed/17320975
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jneuroim.2007.01.012
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