Release of autoinhibition of ASEF by APC leads to CDC42 activation and tumor suppression

Autoinhibition of the Rho guanine nucleotide exchange factor ASEF is relieved by interaction with the APC tumor suppressor. Here we show that binding of the armadillo repeats of APC to a ‘core APC-binding’ (CAB) motif within ASEF, or truncation of the SH3 domain of ASEF, relieves autoinhibition, all...

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Hlavní autoři: Mitin, Natalia, Betts, Laurie, Yohe, Marielle E, Der, Channing J, Sondek, John, Rossman, Kent L
Médium: Artigo
Jazyk:Inglês
Vydáno: 2007
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2716141/
https://ncbi.nlm.nih.gov/pubmed/17704816
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb1290
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