Blockade of interleukin-6 signaling augments regulatory T-cell reconstitution and attenuates the severity of graft-versus-host disease

Graft-versus-host disease (GVHD) is the major complication after allogeneic bone marrow transplantation and is characterized by the overproduction of proinflammatory cytokines. In this study, we have identified interleukin-6 (IL-6) as a critical inflammatory cytokine that alters the balance between...

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Detalhes bibliográficos
Main Authors: Chen, Xiao, Das, Rupali, Komorowski, Richard, Beres, Amy, Hessner, Martin J., Mihara, Masahiko, Drobyski, William R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2009
Assuntos:
Transplantation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2716024/
https://ncbi.nlm.nih.gov/pubmed/19491393
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-01-197178
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